Baptiste Serin will wear the No 9 jersey for France against England at Twickenham on Saturday.
Serin has been preferred to Maxime Machenaud, who is on the bench, with Camille Lopez at flyhalf.
With Wesley Fofana ruled out due to injury, Rémi Lamerat and Gaël Fickou will start in the midfield.
France – 15 Scott Spedding, 14 Noa Nakaitaci, 13 Gaël Fickou, 12 Rémi Lamerat, 11 Virimi Vakatawa, 10 Camille Lopez, 9 Baptiste Serin, 8 Louis Picamoles, 7 Kévin Gourdon, 6 Damien Chouly, 5 Yoann Maestri, 4 Sébastien Vahaamahina, 3 Uini Atonio, 2 Guilhem Guirado (c), 1 Cyril Baille.
Subs: 16 Clément Maynadier, 17 Xavier Chiocci, 18 Rabah Slimani, 19 Arthur Iturria, 20 Loann Goujon, 21 Maxime Machenaud, 22 Yoann Huget, 23 Jean-Marc Doussain.