Arch-rivals Maties and UCT will go head-to-head in Stellenbosch on Monday.
The match will be followed by the showdown between Pukke and Shimlas in Potchefstroom. The other two games will see defending champions Tuks travel to Johannesburg to face last year's wooden spoonists Wits, while just down the road UJ will host the NMMU.
The Cape derby is always a memorable occasion, and with both teams losing heavily in their opening games last week there should be no lack of intensity in front of a packed crowd in Stellenbosch.
Maties coach Chris Rossouw has made no excuses for his team's first-ever loss to the Madibaz last week, and he knows that expectations will be high as they look to bounce back in their first home game of the season.
It will be a completely different story in Potchefstroom, with both Pukke and Shimlas coming off impressive wins in the opening round.
Pukke's big win in Cape Town saw them take top spot on the standings, and they will be hoping to build on that in their first home game against their rivals from Bloemfontein.
In Johannesburg the Madibaz will want to follow up their win against Maties last week with another big effort against a UJ outfit that held Tuks to a fighting draw in Pretoria.
The Madibaz ran in six tries against Maties in Port Elizabeth, but their challenge is to show that they can be just as devastating on the road against a disciplined UJ team.
After being held to a draw at home last week, Tuks will be out to prove a point and rack up a convincing win over Wits who are yet to win a Varsity Cup game.
All of the teams and match details for Monday, 10 February:
MATIES vs UCT
Danie Craven Stadium, Stellenbosch, 16:45 (live on SuperSport)
Maties – 15 Craig Barry, 14 Clearance Khumalo, 13 Mark Hodgskiss, 12 Johnny Kôtze, 11 Caleb Smith, 10 Robert du Preez, 9 Louis Nel, 8 Tertius Daniller (c), 7 Lungelo Chonco, 6 Beyers de Villiers, 5 Wilhelm van der Sluys, 4 Jan de Klerk, 3 Brendon Pitzer, 2 Freddie Kirsten, 1 Niel Oelofse.
Subs: 16 Charl de Villiers, 17 Wesley Adonis, 18 Ian Groenewald, 19 Justin Benn, 20 Jean Nel, 21 Chris Smith, 22 Louis Jordaan, 23 Liam Hendricks.
UCT – 15 Ross Jones-Davies, 14 Richard Stewart, 13 Huw Jones, 12 Guy Schwikkard, 11 Lihleli Xoli, 10 Dean Grant, 9 Liam Slatem (c), 8 Vince Jobo, 7 Shaun McDonald, 6 Jason Klaasen, 5 James Kilroe, 4 Jan Uys, 3 Digby Webb, 2 Neil Rautenbach, 1 Joel Carew.
Subs: 16 Chad Solomon, 17 David Maasch, 18 Guy Alexander, 19 Zakeyo Tinetenda, 20 James Alexander, 21 Martin Sauls, 22 David Strachan, 23 Robin Murray.
PUKKE vs SHIMLAS
Fanie du Toit Sports Ground, Potchefstroom, 19:00 (Live on SuperSport)
Pukke – 15 Sylvian Mahuza, 14 Edmar Marais, 13 Jaap Pienaar, 12 Adriaan Engelbrecht, 11 Luther Obi, 10 Johnny Welthagen, 9 Tiaan Dorfling (c), 8 Juan Language, 7 Henro-Pierre Swart, 6 Rhyk Welgemoed, 5 Francois Robbertse, 4 Peet van Der Walt, 3 Elardus Venter, 2 Armand van Der Merwe, 1 Mashudu Mafela.
Subs: 16 Marius Fourie, 17 Johan Smith, 18 Daniel Jordaan, 19 Robey Labuschagne, 20 Dillon Smit, 21 Rhyno Smith, 22 Lucian Cupido, 23 Lhlanhla Ngoama.
Shimlas – 15 AJ Coertzen, 14 Maphutha Dolo, 13 Robbie van Schalkwyk, 12 Joubert Engelbrecht, 11 Sethu Tom, 10 Gouws Prinsloo, 9 Kevin Luiters, 8 Neill Jordaan, 7 Oupa Mohoje, 6 Tienie Burger, 5 Neil Claasen, 4 Fanie van der Walt, 3 Nick Schonert, 2 Elandré Huggett (c), 1 Rudolf Botha.
Subs: 16 Jacques du Toit, 17 Gideon Bruwer, 18 Johan van der Hoogt, 19 Gerhard Oivier, 20 Kay-Kay Hlongwane, 21 Pieter-Steyn de Wet, 22 Divandré Strydom, 23 Justin Pappin.
UJ vs NMMU
UJ Stadium, Johannesburg, 19:00
UJ – 15 Marais Schmidt, 14 JR Esterhuizen, 13 Robert de Bruyn, 12 Harold Vorster, 11 Jacques Nel, 10 Jaco van der Walt, 9 Jacques Pretorius (c), 8 Kobus Porter, 7 Victor Seketekete, 6 Tiaan MacDonald, 5 David Antonites, 4 Shane Kirkwood, 3 Van Zyl Botha, 2 Francois du Toit, 1 Wiseman Kamanga.
Subs: 16 Jannes Snyman, 17 Devon Martinus, 18 Fabian Booysen, 19 Dylan Peterson, 20 Lukas van Zyl, 21 Juan Kotze, 22 PJ Walters, 23 Hendrik Bredenkamp.
NMMU – 15 Donovan Marais, 14 Tythan Adams, 13 Michael Bernardt, 12 Andile Jho, 11 Yamkela Ngam, 10 Gavin Hauptfleisch, 9 Daniel Acker, 8 Timothy Agaba, 7 Marcel Groenewald, 6 Christopher Cloete, 5 Cameron Lindsay, 4 Stefan Willemse, 3 Dexter Fahey, 2 Martin Ferreira, 1 Roy Godfrey (c).
Subs: 16 Greg Bauer, 17 Nicolas Roebech, 18 Louis Fourie, 19 Wade Elliot, 20 Ivan Ludick, 21 Stefanus Booysen, 22 Ayabula Dlepu, 23 Simon Kerrod.
WITS vs TUKS
Wits Rugby Stadium, Johannesburg, 19:00
Wits – 15 Ruhan Nel, 14 Wilton Petersen, 13 Divan Ferguson, 12 Mandla Dube, 11 Joshua Jarvis, 10 Ashlon Davids, 9 Matt Torrance, 8 Jason Fraser, 7 JJ Breet, 6 JP Jonck, 5 Rinus Bothma, 4 Devin Montgomery (c), 3 Gideon Muller, 2 Ashley Kohler, 1 Kyle Wood.
Subs: 16 Peter van Biljon, 17 James Marx, 18 Rendani Ramovha, 19 Thato Mavundla, 20 Senna Esterhuizen, 21 Nkuli Gamede, 22 Ish Nkolo, 23 Ferdinand Kelly.
Tuks – 15 Warrick Gelant; 14 Jade Stighling, 13 Dries Swanepoel, 12 Ryan Nell, 11 Kefentse Mahlo; 10 Tian Schoeman, 9 Carlo Engelbrecht; 8 Rudolph Smith, 7 Wiaan Liebenberg, 6 Roelof Smit, 5 Reniel Hugo (c), 4 Dennis Visser, 3 Basil Short, 2 Sidney Tobias, 1 Juan Schoeman.
Subs: 16 Corniel Els; 17 Brummer Badenhorst, 18 Jannes Kirsten, 19 Leneve Damens, 20 Emile Temperman; 22 Francois Tredoux, 22 Jacques Rossouw, 23 Andrew Beerwinkel.
Varsity Shield fixtures:
CUT vs UWC (CUT Rugby Stadium, Bloemfontein, 19:00)
TUT vs Fort Hare (TUT Rugby Stadium, Pretoria, 19:00)
Varsity Young Guns fixtures:
Wits Young Guns vs Tuks Young Guns (Wits Rugby Stadium, Johannesburg, 16:45)
UJ Young Guns vs NMMU Young Guns (UJ Stadium, Johannesburg, 16:45)
Young Guns vs UCT Young Guns (Danie Craven Stadium, Stellenbosch, 19:00)
